Low-density lipoprotein in hypercholesterolemic human plasma induces vascular endothelial cell apoptosis by inhibiting fibroblast growth factor 2 transcription Academic Article uri icon

Overview

MeSH Major

  • Apoptosis
  • Endothelium, Vascular
  • Fibroblast Growth Factor 2
  • Hypercholesterolemia
  • Lipoproteins, LDL

abstract

  • Our findings indicate that a highly electronegative, mildly oxidized LDL subfraction present in human hypercholesterolemic but not normolipidemic plasma can induce apoptosis in cultured ECs. The evidence that a freshly isolated LDL species modulates transcription of FGF-2 may provide a physiological insight into the mechanism of vascular EC apoptosis in hypercholesterolemia.

publication date

  • April 29, 2003

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1161/01.CIR.0000065220.70220.F7

PubMed ID

  • 12695302

Additional Document Info

start page

  • 2102

end page

  • 8

volume

  • 107

number

  • 16