Radiolabeled monoclonal antibodies specific to the extracellular domain of prostate-specific membrane antigen: Preclinical studies in nude mice bearing LNCaP human prostate tumor Academic Article uri icon

Overview

MeSH Major

  • Antibodies, Monoclonal
  • Antigens, Surface
  • Carboxypeptidases
  • Indium Radioisotopes
  • Iodine Radioisotopes
  • Prostatic Neoplasms

abstract

  • These results clearly demonstrate that PSMA-specific internalizing antibodies such as J415 and J591 may be the ideal mAbs for the development of novel therapeutic methods to target the delivery of beta-emitting radionuclides ((131)I, (90)Y, and (177)Lu) for the treatment of PSMA-positive tumors. In addition, because J591 and J415 mAbs are specific to PSMA(ext), thus targeting viable tumor, these immunoconjugates are better candidates for targeted radioimmunotherapy than are antibodies targeting PSMA(int).

publication date

  • April 2003

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 12679407

Additional Document Info

start page

  • 610

end page

  • 7

volume

  • 44

number

  • 4