Adenoviral melanoma differentiation-associated gene 7 induces apoptosis in lung cancer cells through mitochondrial permeability transition-independent cytochrome C release Academic Article Article uri icon

Overview

MeSH Major

  • Anthracosis
  • Lung Transplantation

abstract

  • Ad-mda7 induces apoptosis in lung cancer cells through mitochondrial cytochrome c release in a process that is not dependent on mitochondrial membrane potential changes and occurs through mitochondrial permeability transition-independent pores. This unique mechanism of action may allow treatment of patients with lung cancer resistant to mitochondrial permeability transition-dependent cell death processes.

publication date

  • June 2003

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/S0022-5223(02)73247-9

PubMed ID

  • 12830052

Additional Document Info

start page

  • 1328

end page

  • 35

volume

  • 125

number

  • 6