Mature survival results with preoperative cisplatin, protracted infusion 5-fluorouracil, and 44-Gy radiotherapy for esophageal cancer Academic Article Article uri icon


MeSH Major

  • Brain Neoplasms
  • Magnetic Resonance Imaging
  • Radiosurgery


  • The promising 5-year survival results and low rate of late cancer-related deaths suggest that these regimens of intensive neoadjuvant therapy may improve the overall cure rate. The pathologic stage after neoadjuvant therapy is an important predictor of survival and may be useful in selecting patients for novel adjuvant therapies. Isolated local failure is uncommon, indicating that efforts to improve the therapeutic outcome should focus on optimizing systemic therapy rather than intensifying the RT. Additional randomized data are needed to assess the benefits of this therapeutic approach fully.

publication date

  • June 2003



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1016/S0360-3016(02)04598-4

PubMed ID

  • 12738305

Additional Document Info

start page

  • 328

end page

  • 34


  • 56


  • 2