Elevated protein kinase C alpha expression may be predictive of tamoxifen treatment failure Academic Article uri icon

Overview

MeSH Major

  • Breast Neoplasms
  • Protein Kinase C
  • Tamoxifen

abstract

  • We previously reported that stable transfection of protein kinase C alpha (PKCalpha) into T47D human breast cancer cells results in tamoxifen (TAM)-resistant tumour growth. Relevance of PKCalpha expression in clinical specimens was determined by comparing PKCalpha expression in tumours from patients exhibiting disease recurrence with patients remaining disease-free following TAM treatment. Our results suggest that PKCalpha expression may predict TAM treatment failure.

publication date

  • May 6, 2003

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2741052

Digital Object Identifier (DOI)

  • 10.1038/sj.bjc.6600923

PubMed ID

  • 12778068

Additional Document Info

start page

  • 1400

end page

  • 2

volume

  • 88

number

  • 9