Overexpression of the serotonin 5-HT2Breceptor in heart leads to abnormal mitochondrial function and cardiac hypertrophy Academic Article uri icon

Overview

MeSH Major

  • Cardiomegaly
  • Mitochondria
  • Myocardium
  • Receptors, Serotonin

abstract

  • Our results constitute the first genetic evidence that overexpression of the 5-HT2B receptor in the heart leads to compensated hypertrophic cardiomyopathy associated with proliferation of the mitochondria. This observation suggests a role for mitochondria in the hypertrophic signaling that is regulated by serotonin. These transgenic mice provide a new genetic model for hypertrophic heart disease.

publication date

  • July 2003

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1161/01.CIR.0000074224.57016.01

PubMed ID

  • 12810613

Additional Document Info

start page

  • 3223

end page

  • 9

volume

  • 107

number

  • 25