Extracellular crosstalk: When GDNF meets N-CAM Article uri icon

Overview

MeSH Major

  • Axons
  • Embryo Culture Techniques
  • Ganglia, Spinal
  • Neurons
  • Staining and Labeling

abstract

  • N-CAM has now been identified as a receptor for glial cell line-derived neurotrophic factor (GDNF). This finding solves a long-standing question regarding RET-independent GDNF signaling, and reveals a novel pathway distinct from both GDNF-RET and N-CAM-N-CAM signaling. Functional assays of Schwann cell migration and axon growth of CNS neurons suggest physiological significance for this GDNF-N-CAM pathway.

publication date

  • June 27, 2003

Research

keywords

  • Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/S0092-8674(03)00467-7

PubMed ID

  • 12837237

Additional Document Info

start page

  • 814

end page

  • 5

volume

  • 113

number

  • 7