Dendritic cells: Controllers of the immune system and a new promise for immunotherapy Review uri icon

Overview

MeSH Major

  • Dendritic Cells
  • Immunotherapy

abstract

  • The immune system is controlled by dendritic cells (DCs). Just as lymphocytes comprise different subsets, DCs comprise several subsets that differentially control lymphocyte function. In humans, the myeloid pathway includes Langerhans cells (LCs) and interstitial DCs (intDCs). While both subsets produce IL-12, only intDCs make IL-10 and induce B cell differentiation. Another pathway includes plasmacytoid DCs, which promptly secrete large amounts of IFN-alpha/beta viral encounter. Thus, insights into in vivo DC functions are important to understand the launching and modulation of immunity.

publication date

  • May 28, 2003

Research

keywords

  • Review

Identity

Language

  • eng

PubMed ID

  • 12727638

Additional Document Info

start page

  • 180

end page

  • 7

volume

  • 987