Adjuvant Hepatic Arterial Chemotherapy Following Metastasectomy in Patients with Isolated Liver Metastases
Mitogen-Activated Protein Kinases
Wounds and Injuries
Biliary toxicity is an important potential side effect of hepatic arterial chemotherapy. Although larger randomized studies and this one suggest significant improvements in hepatic recurrences, these have not reliably translated into overall survival benefit. This fact, in light of the potential toxicity, would argue for a larger confirmatory trial of HAI in the adjuvant setting, incorporating recent advances in systemic therapy and careful attention to hepatotoxicity.