SHED: Stem cells from human exfoliated deciduous teeth Academic Article uri icon


MeSH Major

  • Stem Cell Transplantation
  • Stem Cells
  • Tooth Exfoliation
  • Tooth, Deciduous


  • To isolate high-quality human postnatal stem cells from accessible resources is an important goal for stem-cell research. In this study we found that exfoliated human deciduous tooth contains multipotent stem cells [stem cells from human exfoliated deciduous teeth (SHED)]. SHED were identified to be a population of highly proliferative, clonogenic cells capable of differentiating into a variety of cell types including neural cells, adipocytes, and odontoblasts. After in vivo transplantation, SHED were found to be able to induce bone formation, generate dentin, and survive in mouse brain along with expression of neural markers. Here we show that a naturally exfoliated human organ contains a population of stem cells that are completely different from previously identified stem cells. SHED are not only derived from a very accessible tissue resource but are also capable of providing enough cells for potential clinical application. Thus, exfoliated teeth may be an unexpected unique resource for stem-cell therapies including autologous stem-cell transplantation and tissue engineering.

publication date

  • May 13, 2003



  • Academic Article



  • eng

PubMed Central ID

  • PMC156282

Digital Object Identifier (DOI)

  • 10.1073/pnas.0937635100

PubMed ID

  • 12716973

Additional Document Info

start page

  • 5807

end page

  • 12


  • 100


  • 10