Phase I study of intranodal delivery of a plasmid DNA vaccine for patients with Stage IV melanoma Academic Article uri icon

Overview

MeSH Major

  • Cancer Vaccines
  • Melanoma
  • Plasmids
  • Skin Neoplasms
  • Vaccines, DNA

abstract

  • Infusion of a DNA plasmid vaccine into a groin lymph node was practical and well tolerated. Immune responses to a novel tyrosinase epitope were noted. Overall survival in this trial of heavily pretreated patients was unexpectedly long, with 16 of 26 patients alive after a follow-up of 12 months, favoring immune responders.

publication date

  • July 2003

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1002/cncr.11462

PubMed ID

  • 12833467

Additional Document Info

start page

  • 144

end page

  • 54

volume

  • 98

number

  • 1