Osteogenic and ewing sarcomas: Estimation of necrotic fraction during induction chemotherapy with dynamic contrastenhanced MR imaging Academic Article uri icon


MeSH Major

  • Magnetic Resonance Imaging
  • Osteosarcoma
  • Sarcoma, Ewing


  • Dynamic contrast material-enhanced magnetic resonance (MR) images of primary osteogenic sarcoma (n = 19) and Ewing sarcoma (n = 10) were reviewed in 29 patients undergoing induction chemotherapy before surgery. Histogram distributions containing the initial slope and pharmacokinetic model parameters from individual voxels within each tumor were fitted for each patient. The histogram analysis of initial slope from the tumor correlated well with percentage necrosis as determined at pathologic examination (r = 0.60, P <.001), as did a two-compartment pharmacokinetic model (r = 0.64, P <.001). Both methods predicted tumors with clinically important degrees of necrosis (ie, > or =90%) in a large majority of cases. The ability to determine response to induction chemotherapy by means of noninvasive monitoring of necrotic fraction with perfusion MR imaging methods may provide useful prognostic information and help surgical planning.

publication date

  • July 2003



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1148/radiol.2281011651

PubMed ID

  • 12832588

Additional Document Info

start page

  • 271

end page

  • 8


  • 228


  • 1