In vitro and in vivo antitumor properties of tetrakis((trishydroxymethyl)phosphine)gold(I) chloride Academic Article uri icon

Overview

MeSH Major

  • Antineoplastic Agents
  • Organometallic Compounds
  • Phosphines

abstract

  • A novel hydrophilic gold compound, tetrakis((trishydroxymethyl)phosphine)gold(I) chloride 1, has been investigated for its antitumor properties. In vitro studies demonstrate that 1 is active against HCT-15, AGS, PC-3, and LNCaP tumor cells. Cell cycle analysis of the HCT-15 cells by flow cytometry revealed elongation of the G1 phase of the cell cycle leading to growth inhibition. Administration of 1 to Balb/C mice inoculated with syngenic meth/A cells demonstrated statistically significant dose-dependent survival time.

publication date

  • March 27, 2003

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1021/jm025615g

PubMed ID

  • 12646023

Additional Document Info

start page

  • 1130

end page

  • 2

volume

  • 46

number

  • 7