Total synthesis as a resource in the discovery of potentially valuable antitumor agents: Cycloproparadicicol Academic Article uri icon

Overview

MeSH Major

  • Antineoplastic Agents
  • Cyclopropanes
  • Lactones

abstract

  • A highly convergent synthesis was used to prepare a series of epimers and analogues of radicicol (1). Biological assessment revealed a previously unrecognized correlation between stereochemistry and antitumor potential in these compounds. Significantly, cycloproparadicicol (2) showed promising therapeutic properties based on inhibition of chaperones.

publication date

  • March 17, 2003

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1002/anie.200390329

PubMed ID

  • 12645064

Additional Document Info

start page

  • 1280

end page

  • 4

volume

  • 42

number

  • 11