TWEAK is an endothelial cell growth and chemotactic factor that also potentiates FGF-2 and VEGF-A mitogenic activity Academic Article uri icon

Overview

MeSH Major

  • Carrier Proteins
  • Chemotactic Factors
  • Endothelium, Vascular
  • Fibroblast Growth Factor 2
  • Mitogens

abstract

  • These results indicate that TWEAK is an EC growth and migration factor but not a survival factor. TWEAK can also enhance both FGF-2 and VEGF-A mitogenic activity on ECs. Thus, TWEAK may act alone as well as in combination with FGF-2 or VEGF-A to regulate pathological angiogenesis.

publication date

  • April 2003

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1161/01.ATV.0000062883.93715.37

PubMed ID

  • 12615668

Additional Document Info

start page

  • 594

end page

  • 600

volume

  • 23

number

  • 4