Human immunodeficiency virus type 1 attachment, coreceptor, and fusion inhibitors are active against both direct and trans infection of primary cells Academic Article Article uri icon


MeSH Major

  • Disease Outbreaks
  • HIV Infections
  • Health Personnel
  • Prisoners
  • Social Justice


  • Inhibitors of human immunodeficiency virus type 1 attachment (CD4-immunoglobulin G subclass 2), CCR5 usage (PRO 140), and fusion (T-20) were tested on diverse primary cell types that represent the major targets both for infection in vivo and for the inhibition of trans infection of target cells by virus bound to dendritic cells. Although minor cell-type-dependent differences in potency were observed, each inhibitor was active on each cell type and trans infection was similarly vulnerable to inhibition at each stage of the fusion cascade.

publication date

  • February 2003



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1128/JVI.77.4.2762-2767.2003

PubMed ID

  • 12552019

Additional Document Info

start page

  • 2762

end page

  • 7


  • 77


  • 4