Patient-specific, 3-dimensional dosimetry in non-Hodgkin's lymphoma patients treated with 131I-anti-B1 antibody: assessment of tumor dose-response. Academic Article uri icon

Overview

MeSH Major

  • Antibodies, Monoclonal
  • Imaging, Three-Dimensional
  • Lymphoma, Non-Hodgkin
  • Radiometry
  • Radiotherapy Planning, Computer-Assisted

abstract

  • This analysis represents the first full reported implementation of a patient-specific 3D dosimetry package. The absence of a dose-response relationship for tumors is surprising and suggests that absorbed dose is not the sole determinant of tumor response in these patients. The absence of a correlation between the total-body tumor burden and overall response or toxicity suggests that tailoring the milligram amount of administered antibody to patient tumor burden is not likely to improve response or reduce toxicity.

publication date

  • February 2003

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 12571219

Additional Document Info

start page

  • 260

end page

  • 8

volume

  • 44

number

  • 2