Cyclooxygenase 2: A molecular target for cancer prevention and treatment Article Report uri icon

Overview

MeSH Major

  • Anti-Inflammatory Agents, Non-Steroidal
  • Cyclooxygenase Inhibitors
  • Indomethacin
  • Prostaglandin-Endoperoxide Synthases
  • Sulindac

abstract

  • Cyclooxygenase2 (COX-2), an inducible prostaglandin G/H synthase, is overexpressed in several human cancers. Here, the potential utility of selective COX-2 inhibitors in the prevention and treatment of cancer is considered. The mechanisms by which COX-2 levels increase in cancers, key data that indicate a causal link between increased COX-2 activity and tumorigenesis, and possible mechanisms of action of COX-2 are discussed. In a proof-of-principle clinical trial, treatment with the selective COX-2 inhibitor celecoxib reduced the number of colorectal polyps in patients with familial adenomatous polyposis. Selective COX-2 inhibitors appear to be sufficiently safe to permit large-scale clinical testing and numerous clinical trials are currently under way to determine whether selective inhibitors of COX-2 are effective in the prevention and treatment of cancer.

publication date

  • February 2003

Research

keywords

  • Report

Identity

Digital Object Identifier (DOI)

  • 10.1016/S0165-6147(02)00043-3

PubMed ID

  • 12559775

Additional Document Info

start page

  • 96

end page

  • 102

volume

  • 24

number

  • 2