Sirolimus may promote thrombotic microangiopathy
Carcinoma, Squamous Cell
Carcinoma, Transitional Cell
Neoplasms, Multiple Primary
In this patient with a renal allograft, conversion from tacrolimus to sirolimus was associated with the appearance of severe thrombotic microangiopathy. Sirolimus discontinuation resulted was followed by full recovery, suggesting that the sirolimus played a role in the thrombotic microangiopathy.