Differential expression of specific FGF ligand and receptor isoforms during angiogenesis associated with prostate cancer progression Academic Article uri icon

Overview

MeSH Major

  • Adenocarcinoma
  • Fibroblast Growth Factors
  • Gene Expression Regulation, Neoplastic
  • Neovascularization, Pathologic
  • Prostatic Neoplasms

abstract

  • By using the TRAMP model, the expression of FGFR1iiib in intraductal vasculature and expression of FGF-2 protein were found to be concomitant with the emergence of PIN. These observations implicate specific changes in the FGF axis with the initiation and progression of prostate cancer and underscore the utility of animal models to identify specific molecular changes in early disease.

publication date

  • January 2003

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1002/pros.10163

PubMed ID

  • 12481250

Additional Document Info

start page

  • 8

end page

  • 16

volume

  • 54

number

  • 1