Differential expression of specific FGF ligand and receptor isoforms during angiogenesis associated with prostate cancer progression
Fibroblast Growth Factors
Gene Expression Regulation, Neoplastic
By using the TRAMP model, the expression of FGFR1iiib in intraductal vasculature and expression of FGF-2 protein were found to be concomitant with the emergence of PIN. These observations implicate specific changes in the FGF axis with the initiation and progression of prostate cancer and underscore the utility of animal models to identify specific molecular changes in early disease.