High frequency of t(11;18) in gastric mucosa-associated lymphoid tissue lymphomas in Taiwan, including one patient with high-grade transformation Academic Article Article uri icon

Overview

MeSH Major

  • Chromosomes, Human, Pair 7
  • Gene Deletion
  • Immunoglobulin G
  • Lymphoma, B-Cell, Marginal Zone
  • Splenic Neoplasms
  • Translocation, Genetic

abstract

  • t(11;18)(q21;q21), the most frequent chromosomal aberration of mucosa-associated lymphoid tissue (MALT) lymphoma, occurs in 30% of gastric patients. Although the translocation is often associated with an 'aggressive' course, it has not been described in transformed MALT lymphomas. We screened 15 gastric MALT lymphomas [three with concurrent or subsequent high-grade transformation and 11 diffuse large B-cell lymphomas (DLBCLs)] in Chinese patients for t(11;18). t(11;18) was found in 9/15 (60%) MALT lymphomas, but not in any DLBCLs. One patient, with subsequent high-grade transformation, showed the translocation in low- and high-grade lesions. t(11;18) was frequent in Chinese gastric MALT lymphomas and unusually one transformed lymphoma carried the translocation.

publication date

  • January 16, 2003

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1046/j.1365-2141.2003.04035.x

PubMed ID

  • 12492583

Additional Document Info

start page

  • 97

end page

  • 100

volume

  • 120

number

  • 1