The phosphoinositide 3-kinase pathway Review uri icon

Overview

MeSH Major

  • Phosphatidylinositol 3-Kinases
  • Phosphatidylinositol Phosphates
  • Signal Transduction

abstract

  • Phosphorylated lipids are produced at cellular membranes during signaling events and contribute to the recruitment and activation of various signaling components. The role of phosphoinositide 3-kinase (PI3K), which catalyzes the production of phosphatidylinositol-3,4,5-trisphosphate, in cell survival pathways; the regulation of gene expression and cell metabolism; and cytoskeletal rearrangements are highlighted. The PI3K pathway is implicated in human diseases including diabetes and cancer, and understanding the intricacies of this pathway may provide new avenues for therapuetic intervention.

publication date

  • May 31, 2002

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1126/science.296.5573.1655

PubMed ID

  • 12040186

Additional Document Info

start page

  • 1655

end page

  • 7

volume

  • 296

number

  • 5573