Integrin-mediated long-term B cell retention in the splenic marginal zone Academic Article uri icon

Overview

MeSH Major

  • B-Lymphocytes
  • Integrins
  • Lymphocyte Function-Associated Antigen-1
  • Receptors, Lymphocyte Homing
  • Spleen

abstract

  • The mechanisms that control localization of marginal zone (MZ) B cells are poorly understood. Here we show that MZ B cells express elevated levels of the integrins LFA-1 (alphaLbeta2) and alpha4beta1 and that they bind to the ligands ICAM-1 and VCAM-1. These ligands are expressed within the MZ in a lymphotoxin-dependent manner. Combined inhibition of LFA-1 and alpha4beta1 causes a rapid and selective release of B cells from the MZ. Furthermore, lipopolysaccharide-triggered MZ B cell relocalization involves down-regulation of integrin-mediated adhesion. These studies identify key requirements for MZ B cell localization and establish a role for integrins in peripheral lymphoid tissue compartmentalization.

publication date

  • July 19, 2002

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1126/science.1071632

PubMed ID

  • 12130787

Additional Document Info

start page

  • 409

end page

  • 12

volume

  • 297

number

  • 5580