Myocardial fibrosis in chronic aortic regurgitation molecular and cellular responses to volume overload Academic Article Article uri icon

Overview

MeSH Major

  • Cardiomegaly
  • Hypertension

abstract

  • In AR, CF produce abnormal proportions of noncollagen ECM, specifically fibronectin, with relatively little change in collagen synthesis. At least in part, this is a primary response to strain imposed on CF by AR. Further study must relate these findings to the pathogenesis of heart failure in AR.

publication date

  • April 16, 2002

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1161/01.CIR.0000014419.71706.85

PubMed ID

  • 11956128

Additional Document Info

start page

  • 1837

end page

  • 42

volume

  • 105

number

  • 15