Combination chemotherapy and radiotherapy for primary central nervous system lymphoma: Radiation Therapy Oncology Group study 93-10 Academic Article uri icon

Overview

MeSH Major

  • Brain Neoplasms
  • Lymphoma

abstract

  • This is the first multicenter trial demonstrating improved survival with the combination of chemotherapy plus RT compared with previous reports of RT alone. A high-dose methotrexate-based regimen produced a high response rate before RT was administered. High-dose methotrexate combined with cranial irradiation is an effective therapeutic approach to PCNSL, but neurotoxicity is a delayed risk of this approach.

publication date

  • December 15, 2002

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1200/JCO.2002.11.013

PubMed ID

  • 12488408

Additional Document Info

start page

  • 4643

end page

  • 8

volume

  • 20

number

  • 24