Proapoptotic bax is hyperexpressed in isolated human islets compared with antiapoptotic BCL-2 Academic Article Article uri icon

Overview

MeSH Major

  • Stomach Neoplasms

abstract

  • Our finding that isolated human islets express Bax at a higher level compared with Bcl-2 suggests a molecular mechanism for islet cell death by apoptosis. We hypothesize that reducing islet expression of Bax, or regulating its activation, will help preserve islet cell mass after islet transplantation.

publication date

  • December 15, 2002

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1097/00007890-200212150-00003

PubMed ID

  • 12490780

Additional Document Info

start page

  • 1489

end page

  • 96

volume

  • 74

number

  • 11