Prognostic value of KIT mutation type, mitotic activity, and histologic subtype in gastrointestinal stromal tumors Academic Article uri icon

Overview

MeSH Major

  • Gastrointestinal Neoplasms
  • Proto-Oncogene Proteins c-kit
  • Stromal Cells

abstract

  • In this series of KIT-expressing GISTs, tumor mitotic activity and histologic subtype were the most important prognostic features. The majority of GISTs contain KIT-activating mutations with the type/location of mutation serving as an independent predictor for disease-free survival. These results suggest that KIT mutation and activation are important in GIST pathogenesis and also may provide important prognostic information.

publication date

  • September 15, 2002

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1200/JCO.2002.03.095

PubMed ID

  • 12228211

Additional Document Info

start page

  • 3898

end page

  • 905

volume

  • 20

number

  • 18