Prognostic value of KIT mutation type, mitotic activity, and histologic subtype in gastrointestinal stromal tumors
Proto-Oncogene Proteins c-kit
In this series of KIT-expressing GISTs, tumor mitotic activity and histologic subtype were the most important prognostic features. The majority of GISTs contain KIT-activating mutations with the type/location of mutation serving as an independent predictor for disease-free survival. These results suggest that KIT mutation and activation are important in GIST pathogenesis and also may provide important prognostic information.