Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors Academic Article uri icon

Overview

MeSH Major

  • Antineoplastic Agents
  • Gastrointestinal Neoplasms
  • Piperazines
  • Protein-Tyrosine Kinases
  • Pyrimidines

abstract

  • Imatinib induced a sustained objective response in more than half of patients with an advanced unresectable or metastatic gastrointestinal stromal tumor. Inhibition of the KIT signal-transduction pathway is a promising treatment for advanced gastrointestinal stromal tumors, which resist conventional chemotherapy.

publication date

  • August 15, 2002

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1056/NEJMoa020461

PubMed ID

  • 12181401

Additional Document Info

start page

  • 472

end page

  • 80

volume

  • 347

number

  • 7