Statins have biphasic effects on angiogenesis Academic Article Article uri icon

Overview

MeSH Major

  • Education, Medical
  • Education, Medical, Continuing
  • Specialization
  • Vascular Diseases

abstract

  • HMG-CoA reductase inhibition has a biphasic dose-dependent effect on angiogenesis that is lipid independent and associated with alterations in endothelial apoptosis and vascular endothelial growth factor signaling. Statins have proangiogenic effects at low therapeutic concentrations but angiostatic effects at high concentrations that are reversed by geranylgeranyl pyrophosphate. At clinically relevant doses, statins may modulate angiogenesis in humans via effects on geranylated proteins.

publication date

  • February 12, 2002

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1161/hc0602.103393

PubMed ID

  • 11839631

Additional Document Info

start page

  • 739

end page

  • 45

volume

  • 105

number

  • 6