Signaling the pathway to regeneration Academic Article Article uri icon

Overview

MeSH Major

  • Biopterin
  • Gene Expression Regulation
  • Inflammation
  • Neuralgia

abstract

  • Robust axon regeneration occurs after peripheral nerve injury through coordinated activation of a genetic program and local intracellular signaling cascades. Although regeneration-associated genes are being identified with increasing frequency, most aspects of regeneration-associated intracellular signaling remain poorly understood. Two independent studies now report that upregulation of cAMP is a component of the PNS regeneration program that can be exploited to enhance axon regeneration through the normally inhibitory CNS environment.

publication date

  • July 3, 2002

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/S0896-6273(02)00762-6

PubMed ID

  • 12123603

Additional Document Info

start page

  • 13

end page

  • 6

volume

  • 35

number

  • 1