Increased myocardial gene expression of tumor necrosis factor-α and nitric oxide synthase-2: A potential mechanism for depressed myocardial function in hibernating myocardium in humans Academic Article Article uri icon

Overview

MeSH Major

  • Echocardiography
  • Heart Neoplasms
  • Myxoma

abstract

  • TNF-alpha and NOS2 gene expression is regionally upregulated in hibernating myocardium to a level intermediate between that of normal regions and ischemic regions without contractile reserve. This, along with a decline in serum cytokine levels after revascularization proportional to the extent of myocardial viability, suggests a contributing role for cardioinhibitory cytokines in the observed depression of function seen in hibernating myocardium.

publication date

  • April 2, 2002

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1161/01.CIR.0000013846.72805.7E

PubMed ID

  • 11927517

Additional Document Info

start page

  • 1537

end page

  • 40

volume

  • 105

number

  • 13