Ovarian cancer risk in Ashkenazi Jewish carriers of BRCA1 and BRCA2 mutations Academic Article uri icon

Overview

MeSH Major

  • BRCA1 Protein
  • BRCA2 Protein
  • Genetic Predisposition to Disease
  • Jews
  • Ovarian Neoplasms

abstract

  • The lifetime penetrances of BRCA1 mutations are lower than estimates obtained using familial data with multiple affected members but larger than estimates from some population-based proband series. The lifetime penetrance estimate of a BRCA2 mutation is in the range reported by some of the studies based on familial data. These results could have implications for clinical counseling, surgical interventions, and screening recommendations in women carrying these founder mutations.

publication date

  • December 2002

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 12473589

Additional Document Info

start page

  • 3776

end page

  • 81

volume

  • 8

number

  • 12