Rare variants of ATM and risk for Hodgkin's disease and radiation-associated breast cancers Academic Article uri icon

Overview

MeSH Major

  • Breast Neoplasms
  • Gene Frequency
  • Hodgkin Disease
  • Neoplasms, Radiation-Induced
  • Protein-Serine-Threonine Kinases

abstract

  • Heterozygous protein-truncating or missense mutations of ATM were not associated with increased radiation-associated risk of BC after HD. The observation of multiple germ-line mutations and a homozygote suggests that rare ATM variants may constitute cancer-susceptibility alleles in a subset of cases.

publication date

  • December 2002

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 12473594

Additional Document Info

start page

  • 3813

end page

  • 9

volume

  • 8

number

  • 12