Tissue microarray molecular profiling of early, node-negative adenocarcinoma of the rectum: A comprehensive analysis Academic Article uri icon

Overview

MeSH Major

  • Adenocarcinoma
  • Biomarkers, Tumor
  • Neoplasm Proteins
  • Nuclear Proteins
  • Rectal Neoplasms

abstract

  • In this homogeneous group of patients with early-stage, node-negative adenocarcinoma of the rectum uniformly treated by surgery alone, the investigated cell cycle-regulatory and proliferation-associated proteins appear to have no prognostic significance. However, down-regulation of p27 appears to be associated with a trend toward reduced DFS and DSS, which suggests further investigation of other p27-related pathways potentially relevant for metastatic disease.

publication date

  • December 2002

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 12473598

Additional Document Info

start page

  • 3841

end page

  • 9

volume

  • 8

number

  • 12