Relation of insulin to left ventricular geometry and function in African American and white hypertensive adults: The HyperGEN study
Diabetes Mellitus, Type 2
Hypertrophy, Left Ventricular
After adjustment for body mass index and other covariates, insulin in nondiabetic hypertensive individuals has weak negative relations to LV chamber size, mass, and stroke volume, and also has weak positive relations to relative wall thickness but not to measures of LV systolic function. Thus, native plasma insulin level may not play a major independent role in the pathogenesis of hypertensive LV hypertrophy or dysfunction.