Synthesis, radiolabeling and preliminary biological evaluation of radiolabeled 5-methyl-6-nitroquipazine, a potential radioligand for the serotonin transporter Academic Article Article uri icon

Overview

MeSH Major

  • Amyloid beta-Peptides
  • Blood Pressure
  • Brain
  • Brain Mapping

abstract

  • 5-Methyl-6-nitroquipazine, a novel analogue of the potent and selective serotonin transporter inhibitor 6-nitroquipazine was synthesized and radiolabeled with tritium and the positron emitter carbon-11. [3H]5-methyl-6-nitroquipazine was found to have a K(d)=51+/-7 pM. The high affinity and the facile labeling of [11C]5-methyl-6-nitroquipazine makes it a promising radioligand for visualization of the serotonin transporter with positron emission tomography.

publication date

  • December 2002

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/S0960-894X(02)00787-4

PubMed ID

  • 12443787

Additional Document Info

start page

  • 3611

end page

  • 3

volume

  • 12

number

  • 24