Anti-heparan sulfate antibodies in neurological disease Academic Article uri icon

Overview

MeSH Major

  • Autoantibodies
  • Heparitin Sulfate
  • Peripheral Nervous System Diseases

abstract

  • Antibodies to heparan sulfate (HS) have previously been found in association with peripheral neuropathy. We tested sera from patients with neuropathies and with other neurological diseases for antibodies to HS using an avidin-biotin enzyme-linked immunosorbent assay (ELISA) system. Increased titers of anti-HS antibodies were found in 3.4% of patients with neuropathy, and in 3% of patients with other neurological diseases. In all cases, however, an inflammatory disease was present, including chronic inflammatory neuropathy, cerebral vasculitis, or multiple sclerosis. Antibodies to HS appear not to be specific for neuropathy, as they occur in several inflammatory diseases. They might contribute to the associated breakdown of the blood-brain or blood-nerve barrier.

publication date

  • November 2002

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1002/mus.10226

PubMed ID

  • 12402295

Additional Document Info

start page

  • 713

end page

  • 5

volume

  • 26

number

  • 5