Celecoxib, a selective cyclooxygenase 2 inhibitor, protects against human epidermal growth factor receptor 2 (HER-2)/neu-induced breast cancer Academic Article uri icon

Overview

MeSH Major

  • Anticarcinogenic Agents
  • Cyclooxygenase Inhibitors
  • Isoenzymes
  • Mammary Neoplasms, Experimental
  • Receptor, ErbB-2
  • Sulfonamides

abstract

  • Cyclooxygenase 2 (HER-2) (Cox-2), an inducible form of Cox, is overexpressed in HER-2/neu-positive human breast cancers. The aim of this study was to determine whether celecoxib, a selective Cox-2 inhibitor, protected against HER-2/neu-induced experimental breast cancer. Cox-2 protein was detected in breast carcinomas from mouse mammary tumor virus (MMTV)/neu mice. Treatment with celecoxib (500 ppm) significantly reduced the incidence of mammary tumors in MMTV/neu mice (P = 0.003) and caused about a 50% reduction in mammary prostaglandin E2 (PGE2) levels. Because mammary glands from MMTV/neu mice expressed all four PGE2 receptor subtypes, we speculate that signaling through PGE2 receptors is important for mammary tumorigenesis. These results strengthen the rationale for developing clinical trials to determine whether selective Cox-2 inhibitors possess anticancer properties in humans at risk for breast cancer.

publication date

  • October 2002

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 12359744

Additional Document Info

start page

  • 5405

end page

  • 7

volume

  • 62

number

  • 19