The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts Academic Article uri icon

Overview

MeSH Major

  • Brucella
  • Genome, Bacterial

abstract

  • The 3.31-Mb genome sequence of the intracellular pathogen and potential bioterrorism agent, Brucella suis, was determined. Comparison of B. suis with Brucella melitensis has defined a finite set of differences that could be responsible for the differences in virulence and host preference between these organisms, and indicates that phage have played a significant role in their divergence. Analysis of the B. suis genome reveals transport and metabolic capabilities akin to soil/plant-associated bacteria. Extensive gene synteny between B. suis chromosome 1 and the genome of the plant symbiont Mesorhizobium loti emphasizes the similarity between this animal pathogen and plant pathogens and symbionts. A limited repertoire of genes homologous to known bacterial virulence factors were identified.

authors

publication date

  • October 2002

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC130601

Digital Object Identifier (DOI)

  • 10.1073/pnas.192319099

PubMed ID

  • 12271122

Additional Document Info

start page

  • 13148

end page

  • 53

volume

  • 99

number

  • 20