PPARĪ³ ligands inhibit primary tumor growth and metastasis by inhibiting angiogenesis Academic Article Article uri icon

Overview

MeSH Major

  • Head and Neck Neoplasms
  • Neoplasm Staging
  • Nomograms
  • Sarcoma

abstract

  • Several drugs approved for a variety of indications have been shown to exhibit antiangiogenic effects. Our study focuses on the PPARgamma ligand rosiglitazone, a compound widely used in the treatment of type 2 diabetes. We demonstrate, for the first time to our knowledge, that PPARgamma is highly expressed in tumor endothelium and is activated by rosiglitazone in cultured endothelial cells. Furthermore, we show that rosiglitazone suppresses primary tumor growth and metastasis by both direct and indirect antiangiogenic effects. Rosiglitazone inhibits bovine capillary endothelial cell but not tumor cell proliferation at low doses in vitro and decreases VEGF production by tumor cells. In our in vivo studies, rosiglitazone suppresses angiogenesis in the chick chorioallantoic membrane, in the avascular cornea, and in a variety of primary tumors. These results suggest that PPARgamma ligands may be useful in treating angiogenic diseases such as cancer by inhibiting angiogenesis.

publication date

  • October 2002

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1172/JCI200215634

PubMed ID

  • 12370270

Additional Document Info

start page

  • 923

end page

  • 32

volume

  • 110

number

  • 7