Acute fibrinous and organizing pneumonia: A histologic pattern of lung injury and possible variant of diffuse alveolar damage Academic Article uri icon


MeSH Major

  • Lung
  • Pneumonia
  • Pulmonary Fibrosis


  • Acute fibrinous and organizing pneumonia is a histologic pattern associated with a clinical picture of acute lung injury that differs from the classic histologic patterns of DAD, BOOP, or EP. Similar to these patterns of acute lung injury, the AFOP pattern can occur in an idiopathic setting or with a spectrum of clinical associations. The overall mortality rate is similar to DAD and therefore may represent a histologic variant; however, AFOP appears to have 2 distinct patterns of disease progression and outcome. The need for mechanical ventilation was the only parameter that correlated with prognosis. None of the patients with a subacute clinical course required mechanical ventilation.

publication date

  • September 2002



  • Academic Article



  • eng

PubMed ID

  • 12204055

Additional Document Info

start page

  • 1064

end page

  • 70


  • 126


  • 9