Volumetric measurement of the hippocampus, the anterior cingulate cortex, and the retrosplenial granular cortex of the rat using structural MRI Academic Article uri icon


MeSH Major

  • Brain Mapping
  • Gyrus Cinguli
  • Hippocampus
  • Lateral Ventricles
  • Magnetic Resonance Imaging
  • Rats, Sprague-Dawley


  • MRI imaging of the rodent brain is a rapidly growing field in the neurosciences. Relatively limited information is available for regional volume determination. The present paper describes a reliable method for the assessment of the hippocampus, the anterior cingulate cortex, the retrosplenial granular cortex and the ventricles in rats. MRI scans were acquired using a 7 T magnet. The anatomical sampling method was found to be highly reliable with an intra-rater reliability of greater than 0.93. The current protocol should facilitate future in vivo neuroimaging research using animal models of neurodegenerative diseases.

publication date

  • August 2002



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1016/S1385-299X(02)00181-2

PubMed ID

  • 12379436

Additional Document Info

start page

  • 41

end page

  • 6


  • 10


  • 1