Safe and cost effective use of alteplase for the clearance of occluded central venous access devices
Catheterization, Central Venous
Tissue Plasminogen Activator
Cryopreserved 1-mg/mL aliquots of alteplase are safe and effective in the clearance of occluded CVADs when stored at -20 degrees C for 30 days. The ability to cryopreserve alteplase aliquots makes it an economically reasonable alternative to urokinase in the setting of CVAD occlusion.