Combined hepatocellular and cholangiocarcinoma: Demographic, clinical, and prognostic factors
Bile Duct Neoplasms
Bile Ducts, Intrahepatic
Neoplasms, Multiple Primary
The demographic and clinical features of patients with combined tumors were most similar to those of patients with CC. Most important, combined tumors were not found to be associated with chronic liver disease; consequently, the resectability rate was higher for these tumors than typically is reported for HCC. Resection was associated with long-term survival in some patients, but recurrent hepatic disease was common. The presence of cholangiocellular differentiation appeared to worsen the prognosis when compared with pure HCC, although this difference did not reach statistical significance.