Association of preoperative plasma levels of insulin-like growth factor I and insulin-like growth factor binding proteins-2 and -3 with prostate cancer invasion, progression, and metastasis Academic Article Article uri icon


MeSH Major

  • Cystectomy
  • Nomograms
  • Urinary Bladder Neoplasms


  • Elevation of plasma IGFBP-2 levels in prostate cancer patients apparently is due to increased release directly from the prostate. For patients with clinically localized prostate cancer, preoperative plasma IGFBP-2 levels are inversely associated with biologically aggressive disease and disease progression. Preoperative plasma IGFBP-3 levels were decreased in patients with prostate cancer metastases and were an independent predictor of biochemical progression after surgery, presumably because of an association with occult metastatic disease present at the time of radical prostatectomy.

publication date

  • February 2002



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1200/JCO.20.3.833

PubMed ID

  • 11821468

Additional Document Info

start page

  • 833

end page

  • 41


  • 20


  • 3