Towards a neurophysiological foundation for cognitive neuromodulation through deep brain stimulation Report uri icon


MeSH Major

  • Brain
  • Cognition
  • Magnetic Resonance Imaging
  • Persistent Vegetative State


  • It may soon be possible to adapt the use of deep brain stimulation (DBS) technologies developed to treat movement disorders to improve the general cognitive function of brain-injured patients. We outline neurophysiological foundations for novel neuromodulation strategies to address these goals. Emphasis is placed on developing a rationale for targeting the intralaminar and related nuclei of the human thalamus for electrical stimulation. Recent anatomical and physiological studies are compared with original neurophysiological recordings obtained in an alert non-human primate. In this context we consider neuronal mechanisms that may underlie both clinical observations and cognitive rehabilitation maneuvers that provide theoretical support for open and closed-loop strategies to remediate acquired cognitive disability (ACD). © 2002 Elsevier Science Ltd. All rights reserved.

publication date

  • January 2002



  • Report


Digital Object Identifier (DOI)

  • 10.1016/S1472-9288(02)00028-6

Additional Document Info

start page

  • 55

end page

  • 69


  • 2


  • 1