The interplay of dendritic cell subsets in systemic lupus erythematosus Review uri icon

Overview

MeSH Major

  • Autoimmune Diseases
  • Dendritic Cells
  • Lupus Erythematosus, Systemic

abstract

  • Dendritic cells (DC) control immunity and tolerance. Hence, we surmised that systemic lupus erythematosus (SLE), a systemic autoimmune disease with autoreactive T and B cells, might be due to DC alterations. Based on our findings, we are proposing a model of SLE where autoimmune responses are driven by unabated activation of myeloid DC through IFN-alpha produced by plasmacytoid DC. Thus, interplay between DC subsets might represent a key component of SLE pathogenesis.

publication date

  • October 5, 2002

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1046/j.1440-1711.2002.01112.x

PubMed ID

  • 12225385

Additional Document Info

start page

  • 484

end page

  • 8

volume

  • 80

number

  • 5