Inv(4)(p14q27) in a case with de novo acute nonlymphocytic leukemia
Chromosomes, Human, Pair 4
Leukemia, Myelomonocytic, Acute
An inversion, inv(4)(p14q27), was found as the sole karyotypic anomaly at diagnosis in the bone marrow cells from a 65-year-old male patient with an M4 acute nonlymphocytic leukemia (ANLL). To our knowledge, the breakpoints observed in this case appear to be different from other inversions of chromosome 4 previously described in ANLL. The patient we described had a poor response to chemotherapy and had a short survival.