Methylthioadenosine phosphorylase gene deletions are common in osteosarcoma Academic Article uri icon

Overview

MeSH Major

  • Bone Neoplasms
  • Cell Cycle Proteins
  • Gene Deletion
  • Osteosarcoma
  • Purine-Nucleoside Phosphorylase
  • Tumor Suppressor Proteins

abstract

  • The MTAP gene is commonly deleted in osteosarcoma patient samples, leading to an absence of mRNA and protein expression; these results indicate that inhibitors of de novo purine synthesis or methionine depletion may be effective as treatments for osteosarcoma patients whose tumors fail to express MTAP.

publication date

  • July 18, 2002

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 11895909

Additional Document Info

start page

  • 782

end page

  • 7

volume

  • 8

number

  • 3