Breast lesions detected on MR imaging: features and positive predictive value. Academic Article uri icon

Overview

MeSH

  • Adult
  • Aged
  • Biopsy, Needle
  • Female
  • Humans
  • Middle Aged
  • Outcome Assessment (Health Care)
  • Predictive Value of Tests
  • Retrospective Studies

MeSH Major

  • Breast Neoplasms
  • Carcinoma
  • Magnetic Resonance Imaging

abstract

  • The purpose of this study was to analyze features of breast lesions detected on MR imaging that had subsequent biopsy and to determine the positive predictive value (PPV) of these features. Retrospective review was performed of 100 consecutive solitary MR imaging-detected breast lesions that had MR imaging-guided needle localization and surgical excision. We described lesions, using terms found in a proposed breast MR imaging lexicon. Histologic findings were reviewed. Carcinoma was identified in 25 lesions (25%), including ductal carcinoma in situ (DCIS) in 13 (52%) and infiltrating carcinoma in 12 (48%). Carcinoma was found in 15 (25%) of 60 masses versus 10 (25%) of 40 nonmass lesions; most malignant masses (73%) were infiltrating carcinoma, whereas most malignant nonmass lesions (90%) were DCIS. The features with the highest PPV were spiculated margin (80% carcinoma), rim enhancement (40% carcinoma), and irregular shape (32% carcinoma) for mass lesions and segmental (67% carcinoma) or clumped linear and ductal enhancement (31% carcinoma) for nonmass lesions. Visually assessed kinetic patterns were not significant predictors of carcinoma, but washout was present in 70% of infiltrating carcinomas versus 9% of DCIS lesions (p < 0.01). Carcinoma was present in 17 (19%) of 88 lesions classified as suspicious versus eight (67%) of 12 lesions classified as highly suggestive of malignancy (p = 0.001). Among MR imaging-detected breast lesions referred for biopsy, carcinoma was found in 25%, of which half were DCIS. Features with the highest PPV were spiculated margin, rim enhancement, and irregular shape for mass lesions and segmental or clumped linear and ductal enhancement for nonmass lesions. Final assessment categories were significant predictors of carcinoma.

publication date

  • July 2002

has subject area

  • Adult
  • Aged
  • Biopsy, Needle
  • Breast Neoplasms
  • Carcinoma
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Middle Aged
  • Outcome Assessment (Health Care)
  • Predictive Value of Tests
  • Retrospective Studies

Research

keywords

  • Journal Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.2214/ajr.179.1.1790171

PubMed ID

  • 12076929

Additional Document Info

start page

  • 171

end page

  • 178

volume

  • 179

number

  • 1